Centrillion Exome+

  • Agilent Sure Select All Exon V4 capture
    • PLUS
  • Centrillion xMHC Target Enrichment
  • Custom probes designed to enrich for:
    • Extended MHC (xMHC) boundaries
    • Exons from GENCODE in xMHC
    • Nine major HLA genes (exons + introns)
    • HLA Class I Antigens
    • HLA Class II Antigens
    • Indels in alternative MHC haplotypes

Exome+ Service Deliverable

  • Sample QC & acceptance
  • Agilent SureSelect Human All Exon + Centrillion xMHC target enrichment
  • Sequencing to desired coverage using Illumina HiSeq2000 or HiSeq2500 instrument
  • Extensive bioinformatics (alignment, variant calls, SNP filtering, annotation)